LOW Vitamin D

Once my more current labs are scanned in you will be able to see my Vitamin D levels are extremely low, but for those of you who know you know that it is very difficult for my Vitamin D levels to go up.  This article might give an idea as to why.

Keep in mind this study was done with Rickets Mutants, or as the article gingerly puts it "Rickets-Associated Mutants"

Rational Design of Vitamin D3 Analogues Which Selectively Restore Activity to a Vitamin D Receptor Mutant Associated with Rickets

Steve L. Swann,, Joel J. Bergh,, M. Cindy Farach-Carson, and, John T. Koh

Organic Letters 2002 4 (22), 3863-3

Vitamin D₃-resistant rickets (VDRR) is associated with mutations to the Vitamin D receptor (VDR) which effect ligand-dependent transactivation...

these examples illustrate that small molecules may be used to restore activity to at least a subset of genetic mutations and suggest a potentially new pharmacological approach to the treatment of genetic disease...

A diverse class of human genetic diseases is associated with mutations to NHRs(nuclear hormone receptors), including androgen insensitivity syndrome (androgen receptor), resistance to thyroid hormone (RTH, thyroid hormone receptor), diabetes mellitus (peroxisome proliferator activated receptor), rickets (VDR), Cushings disease (glucocorticoid receptor), and certain forms of prostate and breast cancer (androgen and estrogen receptors).^7,8(

1. (7)Tenbaum, S.; Baniahmad, A. Int. J. Biochem. Cell Biol. 1997, 29, 1325−1341.

   [CrossRef], [PubMed], [CAS]
2. (8)Maslen, G. L.; Williams, T. D.; Lewis, H.; Schafer, A. J.; Chatterjee, V. K.; O'Rahilly, S.Nature 1999, 402, 880−882.

   [PubMed])

Basically, from what I am getting of the entire article Vitamin D_{3 can not be absorbed by certain mutants because or their mutation.}  

_{I wonder if that is why I cannot absorb} Vitamin D_3?